Specific Language Impairment
Genetics of Specific Language Impairment
Specific language impairment (SLI) is a heritable, idiopathic neurodevelopmental disorder where language ability fails to develop normally despite normal hearing, education and intelligence. Together with Dr. Paula Tallal from Rutgers-Newark and Dr. Anne Bassett from the University of Toronto we have collected a set of families segregating SLI and have mapped a susceptibility locus to chromosome 13q21 (Bartlett et al, American Journal of Human Genetics, 2002). In collaboration with Dr. Christopher Bartlett at the Battelle Center for Mathematical Medicine at The Research Institute at Nationwide Children's Hospital & The Ohio State University, we are conducting further studies to identify specific candidate genes and polymorphisms within those genes that increase risk for SLI.