Rutgers University School of Arts and Sciences Division of Life Sciences
 

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        Welcome to the Schindler Lab webpage!                                                

Our lab studies meiosis, the process that controls female gamete (eggs) formation, with the overall goal of understanding why this process is inherently error prone.  In all sexually reproducing animals, mistakes in meiosis can result in the formation of eggs with the wrong number of chromosomes (aneuploidy) and are highly linked to infertility, miscarriage and developmental disorders such as Down Syndrome.  A surprising number of eggs (an estimated 5-20%) from reproductively young, healthy women are aneuploid and this incidence increases with maternal age.  Little is known, however, about how meiosis in females is regulated.

Work in the Schindler lab takes 2 approaches to try to understand how female meiosis is regulated and why it goes awry frequently in humans. Our basic science approach probes requirements of candidate genes that regulate the cell cycle and chromosome segregation. Over the years, we have focused a lot of efforts on understanding how the Aurora protein kinases regulate meiosis by using mouse knockout models. Informed by human exome sequence data obtained from fertlity clinics, our translational science approach then evaluates human gene variants as potential causes of gamete aneuploidy.

Interested in our work? Follow us on Twitter: @KASchindler727

Our work is generously supported by grants from the NIH (R01-HD091331, R01-GM112801). Previous grants from the NIH include R00-HD061657, F31-HD089597 and from the American Society for Reproductive Medicine, Busch Biomedical Grant Support, the Rutgers Cancer Institute of NJ (P30-CA072720), and the NJ Cancer Commission.