Rutgers University School of Arts and Sciences Division of Life Sciences


  Relevant Publications

1. Nguyen AL, Marin D, Zhou A, Smoak EM, Gentilello AS, Cao Z, Fedick A, Wang Y, Taylor D, Scott RT, Xing J, Treff N, and Schindler K. 2017. Identification and characterization of Aurora Kinase B and C variants associated with maternal aneuploidy. Molecular Human Reproduction. Gax018. Epub ahead of print.

2. Nguyen AL and Schindler K. 2017. Specialize and divide (twice): Functions of 3 Aurora kinase homologs in mammalian oocyte meiotic maturation. Trends in Genetics. 33(5): 349-63.

3. Radford SJ, Nguyen AL, Schindler K, McKim KS. 2016. The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes. Chromosoma. Epub ahead of print. 


4. Balboula AZ, Nguyen AL, Gentilello AS, Quartuccio SM, Drutovic D, Solc P, and

Schindler K. 2016. Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes. Journal of Cell Science. pii:jcs.189340.


5. Ohring J and Schindler K. 2016. A Scrambled Mess. The Scientist. May issue.


6. Fellmeth JE, Ghanaim ES, and Schindler K. 2016. Characterization of

macrozoospermia-associated AURKC mutations in a mammalian meiotic system. Human Molecular Genetics. 25 (13): 2698-2711.


7. Quartuccio SM and Schindler K. 2015. Functions of Aurora kinase C in meiosis and

cancer. Frontiers in Cell and Developmental Biology. 3:50.


8. Fellmeth JE, Gordon D, Robins CE, Scott RT, Treff NR, and Schindler K. 2015.

Expression and characterization of three Aurora kinase C splice variants found in human oocytes. Molecular Human Reproduction. 21(8): 633-44. * Selected for August’s Editor Highlights in MHR


9. Balboula AZ, Stein P, Schultz RM and Schindler K. 2015. RBBP4 regulates histone

deacetylation and bipolar spindle assembly during oocyte maturation in the mouse.

Biology of Reproduction. 92(4): 105, 1-12.


10. Nguyen AL, Gentilello AS, Balboula AZ, Shrivastava V, Ohring J, Schindler K. 2014.

Phosphorylation of threonine 3 on histone 3 by Haspin kinase is required for meiosis I in mouse oocytes. Journal of Cell Science. 127(23): 5066-78. *Featured in “In This Issue” in Journal of Cell Science


11. Balboula AZ and Schindler K. 2014. Selective disruption of Aurora C kinase reveals distinct functions from Aurora B kinase during meiosis in mouse oocytes. PLoS

Genetics, 10(2): e:1004194. *Featured in research highlight in Biology of Reproduction: Schubert C. 2014. Much Ado about Meiosis.


12. Balboula AZ, Stein P, Schultz RM and Schindler K. 2014. Knockdown of RBBP7

unveils a requirement of histone deacetylation for CPC function in mouse oocytes. Cell

Cycle. 13(4): 600-11. * Featured in News and Views in Cell Cycle: De La Fuente R. 2014. Histone deacetylation: Establishing a meiotic histone code 13(6): 879-80.


13. Oh JS, Susor A, Schindler K, Schultz RM, Conti M. 2013. Cdc25A activity is

required for the metaphase II arrest in mouse oocytes. Journal of Cell Science. 126 (Pt 5): 1081-5.


14. Schindler K, Davydenko O, Fram B, Lampson MA, Schultz RM. 2012. Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte

maturation and early development. Proceedings of the National Academy of Sciences

USA. 109(33): E2215-22. * Cover art issue 8/14/12


15. Schindler K. Protein kinases and protein phosphatases that regulate oocyte maturation. A chapter in Cell Cycle and Development by Jacek Kubiak (Ed). 2011. 53: 309-41.


16. Stein P and Schindler K. Mouse oocyte microinjection, maturation and ploidy

 assessment. 2011. Journal of Visualized Experiments. 53: pii 2851.


17. Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA. 2010. Weakened

centromere cohesion is the primary cause of age-related aneuploidy in oocytes. Current Biology. 20(17):1522-8.


18. Buffone MG,* Schindler K,* and Schultz RM. 2009. Over-expression of CDC14B

causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation

embryos. Cell Cycle. 8: 3904-3914. * equal contribution


19. Shuda K,* Schindler K,* Ma J, Schultz RM, and Donovan PJ. 2009. Aurora Kinase

B modulates chromosome alignment in mouse oocytes. Molecular Reproduction and

Development. 76(11): 1094-105. * equal contribution


20. Schindler K, and Schultz RM. 2009. The CDC14A phosphatase regulates oocyte

 maturation in mouse. Cell Cycle. 8(7): 1-9.

21. Schindler K, and Schultz RM. 2009. CDC14B acts through FZR1 (CDH1) to

prevent meiotic maturation of mouse oocytes. Biology of Reproduction. 80(4): 795-803.


22. Moore M, Shin M, Bruning A, Schindler K, Vershon A, and Winter E. 2007. Arg-

Pro-X-Ser/Thr-Ala is a consensus phosphoacceptor sequence for the meiosis-specific

Ime2 protein kinase in Saccharomyces cerevisiae. Biochemistry. 46(1): 271-8.


23. Krishnamoorthy T, Chen X, Govin J, Cheung WL, Dorsey J, Schindler K, Winter E,

Allis CD, Guacci V, Khochbin S, Fuller MT, and Berger SL. 2006. Phosphorylation of

histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse

spermatogenesis. Genes and Development. 20(18): 2580-92.


24. Schindler K, and Winter E. 2006. Phosphorylation of Ime2p regulates meiotic

progression in Saccharomyces cerevisiae. Journal of Biological Chemistry. 281(27):



25. Schindler K, Benjamin KR, Martin A, Boglioli A, Herskowitz I, Winter E. 2003. The

Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p. Molecular and

Cellular Biology. 23(23): 8718-28.


26. Lowe M, Madsen EL, Schindler K, Smith C, Emrich S, Robb F, Halden RU. 2002.

Geochemistry and microbial diversity of a trichloroethene-contaminated Superfund site

undergoing intrinsic in situ reductive dechlorination. FEMS Microbiology and Ecology.

40(2): 123-134.


27. Schaber M, Lindgren A, Schindler K, Bungard D, Kaldis P, Winter E. 2002. CAK1

promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-

independent fashion. Molecular and Cellular Biology. 22(1): 57-68.


28. Kapur R, Majumdar M, Xiao X, McAndrews-Hill M, Schindler K, Williams DA.

1998. Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis. Blood91(3): 879-889.