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The long-term research interest of my laboratory is to understand the mechanisms and consequences of human genomic variation, with focuses on mobile DNA elements, and human disease. We will combine computational and experimental tools to perform genome-wide analyses. With the rapid development of high-throughput sequencing technology and current efforts in understanding human genomic diversity, there are now unprecedented opportunities in human genomics and genetics.
News:
May 20 2013: Our MEScan paper is featured in Nature Reviews Genetics. Full text can be read here: Mobile elements across human populations.
Apr 25 2013: Shuoguo and me will attend the CSHG Biology of Genome meeting this year. Give me a howler if you will be there.
Apr 25 2013: Two papers were recently accepted for publication.
The first study described our improved Mobile Element Scanning (ME-Scan) method and reported more than 2500 new Alu insertion polymorphisms in human populations. The study is published in Genome Research.
In a paper publiseed in BMC Genetics, we performed a meta-analysis on an interleukin-6 polymorphism. The study demonstrated that the CC genotype of this SNPs has a protective effect against preterm brith in European populations.
Please see Publications for detail.
Feb 20 2013: Two papers were accepted for publication.
In a review paper published in Trends in Genetics, we examined recent developments in high-throughput methods for mobile element discovery/genotyping.
In the second study, we developed a trend tests for genetic association study that are robust to sequencing error. This study will appear in the special issue of "Analyzing Rare Variants in Complex Diseases" in Human Heredity.
Please see Publications for detail.
Nov 01 2012: The 1000 Genome Project Phase I paper is publised in Nature. Also, see the news article at ScienceDaily.
Oct 31 2012: I will be at the ASHG meeting next week. Give me a howler if you are there.
Oct 31 2012: The power is back! We missed the worst part of Sandy and the power came back to the campus within a day.
Sep 03 2012: Shuoguo Wang joined the lab as a Postdoctoral Associate. Welcome Shuoguo!
May 20 2012: Two papers have been recently published.
In the first study we examined the high-altitude adaptation of metabolic mechanisms in Tibetans. The paper is published in Molecular Genetics and Metabolism.
In the second study, we assessed the genetic admixutre in a Bolivian population, and developed a set of Ancestry Informative Markers (AIMs) to destinguish American ancestry with other populations. The paper is published in BMC Genetics.
Please see Publications for detail.
Mar 01 2012: Dr. Hongseok Ha joined the lab as a Postdoctoral Associate. Welcome Hongseok!
Jan 24 2012: Happy Chinese New Year!
Our paper studying the pigeon population diversity is published in Current Biology. It has been getting some attention from the press. Here are some press releases:
University of Utah: Birds of a Feather Don’t Always Stick Together [video interview with Dr. Mike Shapiro].
Science Now: High-performance pigeons have a dirty little secret.
Scientific American: Birds of a Feather: Genetic Classification Reveals Pigeons' Exceptional Diversity [Slide Show]
Science Daily: Birds of a Feather Don't Always Stick Together.
Oct 17 2011: One postdoc position is available starting January 2012. Please see the Positions page for detail.
Oct 08 2011: I will be at the ASHG meeting next week. Give me a howler if you are there too!
Last Modified: May 25 2013